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Numerous studies have been done on the effects of ceramides on the skin barrier, including the moisturizing effect, growth of the fibroblast and anti-inflammatory effects among others. Shown below is the comparison of rice based ceramides versus other plant-based ceramides, with rice ceramides and specifically Ceramide-PCD® being the most effective.
Imokawa et al. demonstrated that the content of skin ceramides declines with age. Further studies and findings suggest the ceramides are a key factor in moisture maintenance and barrier function of the stratum corneum and is thought to be a factor in wrinkle formation.
The moisturizing effect of ceramides was established by several clinical studies. These reports showed that ceramides were absorbed into the intestine, circulated into the stratum corneum, and worked to improve barrier and moisturizing function. The moisturizing effects of ORYZA CERAMIDE® were compared with other commercially available ceramides. ORYZA CERAMIDE®–P demonstrated superior moisturizing effect, with a moisture ratio of 35%.
Fibroblasts are a type of cell that synthesizes the extracellular matrix and collagen, the structural frame work for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of connective tissue in animals. Ceramides enhance the proliferation of dermal fibroblast, with rice ceramides exhibiting the most potent proliferative effect.
Besides their moisturizing and barrier effect, ceramides also exhibit anti-allergic and anti-inflammatory activities. Oral administration of rice ceramides decreased scratching action in mice. All the plant-based ceramides inhibited mass cell degeneration, with rice being the most potent.
